HIPO E HIPERPARATIROIDISMO PDFAugust 15, 2020
Además se puede asociar en este síndrome el hipoparatiroidismo, aunque en menor grado, el hipogonadismo, hipotiroidismo y DMID y. Feocromicitoma. Hiperaldosterismo primario. Síndrome de cushing. Hipo- o hipertiroidismo. Hiperparatiroidismo. Síndrome de apnea obstructiva del sueño. Hiperostosis frontal interna, Hiperparatiroidismo neonatal familiar, Hipofosfatasia, Hipofosfatemia, Hipoglicemia inducida por la .
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HIPOPARATIROIDISMO by Jovan Alexander on Prezi
Multiple endocrine neoplasia type 1 MEN 1: These are complex genetic syndromes caused by activation or inactivation of different types of genes known to be involved in the regulation of cell proliferation.
In this review we will discuss the clinical manifestations and management of the MEN 1 syndrome as well as the genetic screening of potential MEN 1 gene carriers. MEN 1 is a hereditary syndrome, transmitted in an autosomic dominant fashion and caused by an inactivating mutation of the MEN 1 gene, characterized by the development of primary hyperparathyroidism, islet cell tumors and pituitary adenomas.
In addition, these patients can present with cutaneous manifestations such as angiofibromas and collagenomas, and can develop other neoplastic manifestations including carcinoids, thyroid tumors, adrenal adenomas, lipomas, pheochromocytomas and meningiomas.
The MEN 1 gene encodes a peptide which is a tumor suppressor gene called menin. Several studies have demonstrated its importance in regulation of cell proliferation and have hiperparatirokdismo its role in the pathogenesis of the MEN 1 syndrome.
The discovery of the MEN 1 gene and the genetic analysis of MEN 1 patients have resulted in earlier diagnosis and treatment of asymptomatic carriers which can potentially result in a longer survival of these patients.
Further investigation of the function and signaling pathways of the menin protein will hopefully offer therapeutic alternatives to patients with malignant progression of MEN 1-related tumors and also result in improved survival. Multiple Endocrine Neoplasia type 1; Primary hyperparathyroidism; Islet cell tumor; Pituitary adenoma; Biochemical and genetic screening. O hiperparairoidismo deve ser individualizado de acordo com o tipo de tumor.
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